Email updates

Keep up to date with the latest news and content from Trials and BioMed Central.

Open Access Study protocol

Alzheimer’s disease multiple intervention trial (ADMIT): study protocol for a randomized controlled clinical trial

Christopher M Callahan123*, Malaz A Boustani123, Arlene A Schmid45, Mary G Austrom67, Douglas K Miller123, Sujuan Gao138, Carrie S Morris9, Mickey Vogel9 and Hugh C Hendrie136

Author Affiliations

1 Indiana University Center for Aging Research, 410 West 10th Street, Indianapolis, IN, 46202-3012, USA

2 Department of Medicine, Indiana University School of Medicine, 714 North Senate Avenue, Indianapolis, IN, 46202-5178, USA

3 Regenstrief Institute, Inc, 1050 Wishard Boulevard, Indianapolis, IN, 46202-2872, USA

4 Department of Occupational Therapy, Indiana University School of Rehabilitation Science, 1140 West Michigan Street, Indianapolis, IN, 46202-5199, USA

5 Roudebush Veterans Affairs Medical Center, 1481 West 10th Street, Indianapolis, IN, 46202-2884, USA

6 Department of Psychiatry, Indiana University School of Medicine, 714 North Senate Avenue, Indianapolis, IN, 46202-5178, USA

7 Indiana Alzheimer Disease Center, 635 Barnhill Drive, Indianapolis, IN, 46202-5120, USA

8 Department of Biostatistics, Indiana University School of Medicine, 714 North Senate Avenue, Indianapolis, IN, 46202-5120, USA

9 Wishard Health Services, 1001 West 10th Street, Indianapolis, IN, 46202-2879, USA

For all author emails, please log on.

Trials 2012, 13:92  doi:10.1186/1745-6215-13-92

Published: 27 June 2012

Abstract

Background

Given the current lack of disease-modifying therapies, it is important to explore new models of longitudinal care for older adults with dementia that focus on improving quality of life and delaying functional decline. In a previous clinical trial, we demonstrated that collaborative care for Alzheimer’s disease reduces patients’ neuropsychiatric symptoms as well as caregiver stress. However, these improvements in quality of life were not associated with delays in subjects’ functional decline.

Trial design

Parallel randomized controlled clinical trial with 1:1 allocation.

Participants

A total of 180 community-dwelling patients aged ≥45 years who are diagnosed with possible or probable Alzheimer’s disease; subjects must also have a caregiver willing to participate in the study and be willing to accept home visits. Subjects and their caregivers are enrolled from the primary care and geriatric medicine practices of an urban public health system serving Indianapolis, Indiana, USA.

Interventions

All patients receive best practices primary care including collaborative care by a dementia care manager over two years; this best practices primary care program represents the local adaptation and implementation of our prior collaborative care intervention in the urban public health system. Intervention patients also receive in-home occupational therapy delivered in twenty-four sessions over two years in addition to best practices primary care. The focus of the occupational therapy intervention is delaying functional decline and helping both subjects and caregivers adapt to functional impairments. The in-home sessions are tailored to the specific needs and goals of each patient-caregiver dyad; these needs are expected to change over the course of the study.

Objective

To determine whether best practices primary care plus home-based occupational therapy delays functional decline among patients with Alzheimer’s disease compared to subjects treated in the control group.

Outcomes

The primary outcome is the Alzheimer’s Disease Cooperative Studies Group Activities of Daily Living Scale; secondary outcome measures are two performance-based measures including the Short Physical Performance Battery and Short Portable Sarcopenia Measure. Outcome assessments for both the caregiver-reported scale and subjects’ physical performance scales are completed in the subject’s home.

Randomization

Eligible patient-care giver dyads will be stratified by clinic type and block randomized with a computer developed randomization scheme using a 1:1 allocation ratio.

Blinding

Single blinded. Research assistants completing the outcome assessments were blinded to the subjects’ treatment group.

Trial status

Ongoing

ClinicalTrial.Gov identifier

NCT01314950; date of completed registration 10 March 2011; date first patient randomized 9 March 2011

Keywords:
Alzheimer’s disease; behavioral interventions; functional decline; primary care