Study protocol  

Comparison of prasugrel and clopidogrel reloading on high platelet reactivity in clopidogrel-loaded patients undergoing percutaneous coronary intervention (PRAISE-HPR): a study protocol for a prospective randomized controlled clinical trial

Dong-Hyun Lee, Moo Hyun Kim, Tae-Ho Park, Jong Sung Park, Kyungil Park, Hong-Zhe Zhang, Jeong-Min Seo, Michael S Lee Trials 2013, 14:62 (28 February 2013)

Abstract | Full text | PDF | PubMed

Study protocol  

Exploring effective core drug patterns in primary insomnia treatment with Chinese herbal medicine: study protocol for a randomized controlled trial

Shiyan Yan, Runshun Zhang, Xuezhong Zhou, Peng Li, Liyun He, Baoyan Liu Trials 2013, 14:61 (28 February 2013)

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Study protocol  

A 12-week multidomain intervention versus active control to reduce risk of Alzheimer’s disease: study protocol for a randomized controlled trial

Kaarin J Anstey, Alex Bahar-Fuchs, Pushpani Herath, George W Rebok, Nicolas Cherbuin Trials 2013, 14:60 (27 February 2013)

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Study protocol  

Should I eXtract Every Six dental trial (SIXES): study protocol for a randomized controlled trial

Nicola Innes, Felicity Borrie, David Bearn, Dafydd Evans, Petra Rauchhaus, Steve McSwiggan, Lyndie Page, Fiona Hogarth Trials 2013, 14:59 (27 February 2013)

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Study protocol  

Dressing wear time after breast reconstruction: study protocol for a randomized controlled trial

Daniela Veiga, Joel Veiga-Filho, Carlos Américo Veiga Damasceno, Edilaine Maria Leci Sales, Thiago Morais, Wânia Almeida, Neil Novo, Lydia Ferreira Trials 2013, 14:58 (22 February 2013)

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Study protocol  

The effectiveness and cost-effectiveness of spinal cord stimulation for refractory angina (RASCAL study): study protocol for a pilot randomized controlled trial

Sam Eldabe, John Raphael, Simon Thomson, Andrea Manca, Mark de Belder, Rajesh Aggarwal, Matthew Banks, Morag Brookes, Susan Merotra, Rashidat Adeniba, Ed Davies, Rod S Taylor Trials 2013, 14:57 (22 February 2013)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

Study protocol  

Efficacy and safety of 12 versus 48 months of dual antiplatelet therapy after implantation of a drug-eluting stent: the OPTImal DUAL antiplatelet therapy (OPTIDUAL) trial: study protocol for a randomized controlled trial

Gérard Helft, Claude Le Feuvre, Jean Louis Georges, Didier Carrie, Florence Leclercq, Hélène Eltchaninoff, Alain Furber, Fabrice Prunier, Laurent Sebagh, Simon Cattan, Guillaume Cayla, Eric Vicaut, Jean-Philippe Metzger Trials 2013, 14:56 (21 February 2013)

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Study protocol  

Improving community development by linking agriculture, nutrition and education: design of a randomised trial of “home-grown” school feeding in Mali

Edoardo Masset, Aulo Gelli Trials 2013, 14:55 (21 February 2013)

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Methodology  

Qualitative research within trials: developing a standard operating procedure for a clinical trials unit

Frances Rapport, Mel Storey, Alison Porter, Helen Snooks, Kerina Jones, Julie Peconi, Antonio Sánchez, Stefan Siebert, Kym Thorne, Clare Clement, Ian Russell Trials 2013, 14:54 (21 February 2013)

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Study protocol  

Bronchiectasis exacerbation study on azithromycin and amoxycillin-clavulanate for respiratory exacerbations in children (BEST-2): study protocol for a randomized controlled trial

Anne B Chang, Keith Grimwood, Andrew C Wilson, Peter P van Asperen, Catherine A Byrnes, Kerry-Ann F O’Grady, Theo P Sloots, Colin F Robertson, Paul J Torzillo, Gabrielle B McCallum, Ian B Masters, Helen M Buntain, Ian M Mackay, Jacobus Ungerer, Joanne Tuppin, Peter S Morris Trials 2013, 14:53 (20 February 2013)

Abstract | Full text | PDF | PubMed

Study protocol  

Zinc supplementation in pre-diabetes: study protocol for a randomized controlled trial

Priyanga Ranasinghe, Ranil Jayawardena, ASAD Pigera, Prasad Katulanda, Godwin R Constantine, Priyadarshani Galappaththy Trials 2013, 14:52 (19 February 2013)

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Study protocol  

Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction – a randomised placebo-controlled trial (KARE): study protocol

Laurence JM Cross, Cecilia M O’Kane, Cliona McDowell, Jospeh J Elborn, Michael A Matthay, Daniel F McAuley Trials 2013, 14:51 (18 February 2013)

Abstract | Full text | PDF | ePUB | PubMed

Research  

The addition of a goal-based motivational interview to treatment as usual to enhance engagement and reduce dropouts in a personality disorder treatment service: results of a feasibility study for a randomized controlled trial

Mary McMurran, W Miles Cox, Diane Whitham, Lucy Hedges Trials 2013, 14:50 (17 February 2013)

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Research  

Evaluation of surgically assisted rapid maxillary expansion with piezosurgery versus oscillating saw and chisel osteotomy - a randomized prospective trial

Majeed Rana, Nils-Claudius Gellrich, Madiha Rana, Jozsef Piffkó, Wolfgang Kater Trials 2013, 14:49 (17 February 2013)

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Study protocol  

Improving adherence to web-based cessation programs: a randomized controlled trial study protocol

Amanda L Graham, Sarah Cha, George D Papandonatos, Nathan K Cobb, Aaron Mushro, Ye Fang, Raymond S Niaura, David B Abrams Trials 2013, 14:48 (17 February 2013)

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Study protocol  

Sentinel node in ovarian cancer: study protocol for a phase 1 study

Marjolein Kleppe, Toon Van Gorp, Brigitte FM Slangen, Arnold J Kruse, Boudewijn Brans, Ivo NA Pooters, Koen K Van de Vijver, Roy FPM Kruitwagen Trials 2013, 14:47 (15 February 2013)

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Study protocol  

A phase II, sham-controlled, double-blinded study testing the safety and efficacy of the coronary sinus reducer in patients with refractory angina: study protocol for a randomized controlled trial

E Marc Jolicœur, Shmuel Banai, Timothy D Henry, Marc Schwartz, Serge Doucet, Christopher J White, Elazer Edelman, Stefan Verheye Trials 2013, 14:46 (15 February 2013)

Abstract | Full text | PDF | PubMed

Study protocol  

Assessing the effectiveness and safety of liposomal paclitaxel in combination with cisplatin as first-line chemotherapy for patients with advanced NSCLC with regional lymph-node metastasis: study protocol for a randomized controlled trial (PLC-GC trial)

Luo Hu, Gong Liang, Wang Yuliang, Zhu Bingjing, Zhou Xiangdong, Xu Rufu Trials 2013, 14:45 (15 February 2013)

Abstract | Full text | PDF | PubMed

Study protocol  

Pylorus resection or pylorus preservation in partial pancreatico-duodenectomy (PROPP study): study protocol for a randomized controlled trial

Thilo Hackert, Thomas Bruckner, Colette Dörr-Harim, Markus K Diener, Phillip Knebel, Werner Hartwig, Oliver Strobel, Stefan Fritz, Lutz Schneider, Jens Werner, Markus W Büchler Trials 2013, 14:44 (14 February 2013)

Abstract | Full text | PDF | PubMed

Study protocol  

Phenylephrine versus ephedrine on cerebral perfusion during carotid endarterectomy (PEPPER): study protocol for a randomized controlled trial

Claire WA Pennekamp, Rogier V Immink, Wolfgang F Buhre, Frans L Moll, Gert Jan de Borst Trials 2013, 14:43 (14 February 2013)

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Study protocol  

A pilot study of intraocular use of intensive anti-inflammatory; triamcinolone acetonide to prevent proliferative vitreoretinopathy in eyes undergoing vitreoretinal surgery for open globe trauma; the adjuncts in ocular trauma (AOT) trial: study protocol for a randomised controlled trial

Philip J Banerjee, Malcolm G Woodcock, Catey Bunce, Robert Scott, David G Charteris Trials 2013, 14:42 (13 February 2013)

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Commentary  

A proposal for reducing the effect of one of many causes of publication bias

Sue M Richards, Julie A Burrett Trials 2013, 14:41 (12 February 2013)

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Research  

Randomized controlled trial comparing telephone and mail follow-up for recruitment of participants into a clinical trial of colorectal cancer screening

Arthur D Wong, John Kirby, Gordon H Guyatt, Paul Moayyedi, Parag Vora, John J You Trials 2013, 14:40 (11 February 2013)

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Study protocol  

A nurse- and peer-led support program to assist women in gynaecological oncology receiving curative radiotherapy, the PeNTAGOn study (Peer and nurse support trial to assist women in gynaecological oncology): study protocol for a randomised controlled trial

Penelope Schofield, Ilona Juraskova, Rebecca Bergin, Karla Gough, Linda Mileshkin, Meinir Krishnasamy, Kate White, David Bernshaw, Sylvia Penberthy, Sanchia Aranda Trials 2013, 14:39 (11 February 2013)

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Study protocol  

Comparison of a drug-eluting balloon first and then bare metal stent with a drug-eluting stent for treatment of de novo lesions: study protocol of a randomized controlled trial

Sang-Don Park, Chang-Hwan Yoon, Il-Young Oh, Jung-Won Suh, Young-Suk Cho, Tae-Jin Youn, Dong-Ju Choi, In-Ho Chae Trials 2013, 14:38 (8 February 2013)

Abstract | Full text | PDF | PubMed

Study protocol  

Effect of intermediate care on mortality following emergency abdominal surgery. The InCare trial: study protocol, rationale and feasibility of a randomised multicentre trial

Morten Vester-Andersen, Tina Waldau, Jørn Wetterslev, Morten Hylander Møller, Jacob Rosenberg, Lars Nannestad Jørgensen, Inger Gillesberg, Henrik Loft Jakobsen, Egon Godthåb Hansen, Lone Musaeus Poulsen, Jan Skovdal, Ellen Kristine Søgaard, Morten Bestle, Jesper Vilandt, Iben Rosenberg, Rasmus Ehrenfried Berthelsen, Jens Pedersen, Mogens Rørbæk Madsen, Thomas Feurstein, Malene Just Busse, Johnny D H Andersen, Christian Maschmann, Morten Rasmussen, Christian Jessen, Lasse Bugge, Helle Ørding, Ann Merete Møller Trials 2013, 14:37 (2 February 2013)

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Study protocol  

The impact of hotspot-targeted interventions on malaria transmission: study protocol for a cluster-randomized controlled trial

Teun Bousema, Jennifer Stevenson, Amrish Baidjoe, Gillian Stresman, Jamie T Griffin, Immo Kleinschmidt, Edmond J Remarque, John Vulule, Nabie Bayoh, Kayla Laserson, Meghna Desai, Robert Sauerwein, Chris Drakeley, Jonathan Cox Trials 2013, 14:36 (2 February 2013)

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Study protocol  

The effects on depression of Internet-administered behavioural activation and physical exercise with treatment rationale and relapse prevention: study protocol for a randomised controlled trial

Per Carlbring, Philip Lindner, Christopher Martell, Peter Hassmén, Lars Forsberg, Lars Ström, Gerhard Andersson Trials 2013, 14:35 (2 February 2013)

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Study protocol  

Effectiveness of occupational therapy in Parkinson’s disease: study protocol for a randomized controlled trial

Ingrid HWM Sturkenboom, Maud J Graff, George F Borm, Eddy MM Adang, Maria WG Nijhuis-van der Sanden, Bastiaan R Bloem, Marten Munneke Trials 2013, 14:34 (2 February 2013)

Abstract | Full text | PDF | PubMed

Research  

Long-term consistent use of a vaginal microbicide gel among HIV-1 sero-discordant couples in a phase III clinical trial (MDP 301) in rural south-west Uganda

Andrew Abaasa, Angela Crook, Mitzy Gafos, Zacchaeus Anywaine, Jonathan Levin, Symon Wandiembe, Ananta Nanoo, Andrew Nunn, Sheena McCormack, Richard Hayes, Anatoli Kamali Trials 2013, 14:33 (1 February 2013)

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Study protocol  

Use of the PiCCO system in critically ill patients with septic shock and acute respiratory distress syndrome: a study protocol for a randomized controlled trial

Zhongheng Zhang, Xiao Xu, Min Yao, Huilan Chen, Hongying Ni, Haozhe Fan Trials 2013, 14:32 (1 February 2013)

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