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Open Access Open Badges Study protocol

Effect of eccentric isokinetic strengthening in the rehabilitation of patients with knee osteoarthritis: Isogo, a randomized trial

Anne-Gaëlle Jegu13, Bruno Pereira2, Nicolas Andant2* and Emmanuel Coudeyre3

Author Affiliations

1 CHU Réunion, Service de Médecine Physique et Réadaptation, Site du Tampon, GHSR Saint-Pierre, Saint Pierre BP 350-97448, France

2 CHU Clermont-Ferrand, Biostatistics Unit, Délégation Recherche Clinique & Innovation (DRCI), Villa annexe IFSI, Clermont-Ferrand F-63003, France

3 Service de Médecine Physique et de Réadaptation, Clermont University, Université d’Auvergne, F-63000 Clermont-Ferrand; CHU Clermont-Ferrand, 58, rue de Montalembert, Clermont-Ferrand F-63000, France

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Trials 2014, 15:106  doi:10.1186/1745-6215-15-106

Published: 2 April 2014



Femorotibial knee osteoarthritis is associated with muscle weakness in the lower limbs, particularly in the quadriceps, which results in disease progression. The interest of having muscular strengthening as part of the therapeutic arsenal for the medical treatment of knee osteoarthritis is now well established.

The functional disability induced by knee osteoarthritis manifests itself principally when walking, notably downhill, during which the muscles are called upon to contract eccentrically.

We can therefore think that eccentric muscular strengthening could bring a functional benefit that is superior to concentric muscular strengthening.


This is a prospective, randomized, bicenter, parallel-group, international study. Eighty patients aged from 40 to 75 years old, suffering from medical-stage knee osteoarthritis, will undertake 6 weeks of isokinetic muscular strengthening. Randomization determines the mode of muscular strengthening: either exclusively eccentric or exclusively concentric.

The principal objective is to demonstrate the superiority of the improvement in the quadriceps isokinetic torque after isokinetic muscular strengthening by the eccentric mode compared to the concentric mode.

The following parameters are also evaluated: the variations in the level of pain, the parameters of walking (maximum speed over 10 and 200 meters, analysis on a computerized Gaitrite™ treadmill), static equilibrium (on a FUSYO™ force platform), and the functional status of the patient using the Western Ontario and MacMaster Universities osteoarthritis index (WOMAC) questionnaire after the strengthening period and at 6 months.


A better knowledge of the most effective mode of muscular strengthening is needed to optimize the functional benefits to the patients. In case of superiority in terms of efficacy of the eccentric mode, the latter could be given priority in the rehabilitation treatment of knee osteoarthritis patients.

Trial registration

Clinical number: NCT01586130.

Eccentric; strength; isokinetic; knee osteoarthritis; rehabilitation