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Open Access Study protocol

Continuous intra-articular infusion anesthesia for pain control after total knee arthroplasty: study protocol for a randomized controlled trial

Da Guo1, Xue-Wei Cao1, Jin-Wen Liu1, Wen-Wei Ouyang2, Jian-Ke Pan1 and Jun Liu1*

Author Affiliations

1 Department of Orthopedic Surgery, The Second School of Clinical Medicine, Guangzhou University of Chinese Medicine, No. 111 Dade Road, Guangzhou, Guangdong 510120, China

2 The Clinical Epidemiology Application Laboratory, The Second School of Clinical Medicine, Guangzhou University of Chinese Medicine, No. 111 Dade Road, Guangzhou, Guangdong 510120, China

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Trials 2014, 15:245  doi:10.1186/1745-6215-15-245

Published: 23 June 2014

Abstract

Background

Postoperative pain control after total knee arthroplasty (TKA) remains a great challenge. The management of pain in the immediate postoperative period is one of the most critical aspects to allow speedier rehabilitation and reduce the risk of postoperative complications. Recently, periarticular infiltration anesthesia has become popular, but the outcome is controversial. Some studies have shown transient effects, “rebound pain”, or no effectiveness in pain control. Continuous intra-articular infusion technique has been introduced to improve these transient effects, but more clinical studies are needed. Furthermore, the potential risk of early periprosthetic joint infection is causing concerning. We plan to compare continuous intra-articular infusion anesthesia with epidural infusion anesthesia after TKA to assess the effectiveness of this technique in reducing pain, in improving postoperative function, and to look at the evidence for risk of early infection.

Methods/design

This trial is a randomized, controlled study. Patients (n = 214) will be randomized into two groups: to receive continuous intra-articular infusion anesthesia (group C); and epidural infusion anesthesia (group E). For the first 3 postoperative days, pain at rest, active range of motion (A-ROM), rescue analgesia and side effects will be recorded. At 3-month and 6-month follow-up, A-ROM, C-reactive protein, erythrocyte sedimentation rate, and synovial fluid cell count and culture will be analyzed.

Discussion

The results from this study will provide clinical evidence on the efficacy of a continuous intra-articular infusion technique in reducing pain, postoperative functional improvement and safety. It will be the first randomized controlled trial to investigate infection risk with local anesthesia after TKA.

Trial registration

ClinicalTrials.gov identifier: ChiCTR-TRC-13003999

Keywords:
Total knee arthroplasty; Postoperative pain control; Continuous intra-articular infusion anesthesia; Randomized controlled trial