|
Sensitivity analysis. Net benefit when relative risk and NNTt are varied. |
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| Relative Risk |
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|
|
|||||
| NNTt |
Cut-off for risk of recurrence |
0.75 |
0.8 |
0.85 |
0.9 |
|
|
|||||
| 10 |
10% |
-0.00710 |
-0.0162 |
-0.02530 |
-0.03440 |
| 25% |
0.00880 |
0.00160 |
-0.00560 |
-0.01280 |
|
| 50% |
0.01090 |
0.00620 |
0.00150 |
-0.00320 |
|
| 15 |
10% |
0.01043 |
0.00133 |
-0.00777 |
-0.01687 |
| 25% |
0.01787 |
0.01067 |
0.00347 |
-0.00373 |
|
| 50% |
0.01510 |
0.01040 |
0.00570 |
0.00100 |
|
| 20 |
10% |
0.01920 |
0.01010 |
0.00100 |
-0.00810 |
| 25% |
0.02240 |
0.01520 |
0.00800 |
0.00080 |
|
| 50% |
0.01720 |
0.01250 |
0.00780 |
0.00310 |
|
| 25 |
10% |
0.02446 |
0.01536 |
0.00626 |
-0.00284 |
| 25% |
0.02512 |
0.01792 |
0.01072 |
0.00352 |
|
| 50% |
0.01846 |
0.01376 |
0.00906 |
0.00436 |
|
| 33 |
10% |
0.02956 |
0.02046 |
0.01136 |
0.00226 |
| 25% |
0.02776 |
0.02056 |
0.01336 |
0.00616 |
|
| 50% |
0.01968 |
0.01498 |
0.01028 |
0.00558 |
|
|
The relative risk of the intervention is 0.75, the NNTt is 33 and the event rate in the absence of intervention is 20%. The decrease in event rate is the event rate in the population in the absence of intervention minus the event rate in the population when individuals meeting the high-risk definition receive intervention. | |||||
Vickers et al. Trials 2006 7:30 doi:10.1186/1745-6215-7-30 |
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