Table 4

Net benefit for treating high-risk and all patients, varying the event rate in the absence of intervention.

Event rate in the absence of intervention
Net benefit (high-risk)
Net benefit (treat all)
Net benefit compared to treat all

50%
0.09713
0.12000
-0.02288
10%
0.01803
0.02000
-0.00198
7.5%
0.01308
0.01375
-0.00067
5%
0.00814
0.00750
0.00064
2.5%
0.00319
0.00125
0.00194
1%
0.00023
-0.00250
0.00273

Results are for a scenario where relative risk = 0.75; sensitivity = 80%; specificity = 65% and NNTt = 200

Vickers et al. Trials 2006 7:30   doi:10.1186/1745-6215-7-30