Methodology

Seminars may increase recruitment to randomised controlled trials: lessons learned from WISDOM

Bronwen J Paine^1,2 , Nigel P Stocks² and Alastair H MacLennan¹

¹Department of Obstetrics & Gynaecology, The University of Adelaide, Adelaide 5005, Australia

²Department of General Practice, The University of Adelaide, Adelaide 5005, Australia

author email corresponding author email

Trials 2008, 9:5doi:10.1186/1745-6215-9-5

Published:	29 January 2008

Abstract

Background

Recruiting patients to large randomised controlled trials (RCTs) in the primary care setting can be challenging. Research teams need to identify and utilise strategies that both maximise the efficiency of recruitment and minimise the burden on general practitioners.

Purpose

To describe our methods for identifying, approaching and recruiting female patients aged 50–69 years to a long-term double-blind RCT of hormone therapy (HT) – the Women's International Study of long Duration Oestrogen after Menopause (WISDOM). The effectiveness of conducting group seminars with patients prior to one-to-one screening is discussed.

Methods

Female patients aged between 50 and 69 years were sent letters from participating general practitioners in Adelaide inviting them to participate in WISDOM and attend an initial seminar providing information about HT and the trial prior to a screening interview with a trial nurse. Recruitment rates for those who did or did not attend group seminars were compared.

Results

Women who attended a group seminar conducted by the research team were twice as likely to attend an initial screening visit and enrol to participate in WISDOM than women who did not attend a seminar (p < 0.001). In addition, it was estimated that the time required to randomise a woman in the trial, and the number and duration of telephone calls to screen out uninterested women, was reduced for the seminar group.

Conclusion

Conducting group seminars with potential participants may be a useful strategy for maximising recruitment from general practice, by increasing patient information and reducing a research team's workload.

Trial registration

Current Controlled Trials ISRCTN63718836