Most Recent Articles: Trialshttps://trialsjournal.biomedcentral.comMost Recent Articles: TrialsFlexor Injury Rehabilitation Splint Trial (FIRST): protocol for a pragmatic randomised controlled trial comparing three splints for finger flexor tendon repairshttps://trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-08013-zWithout surgical repair, flexor tendon injuries do not heal and patients’ ability to bend fingers and grip objects is impaired. However, flexor tendon repair surgery also requires optimal rehabilitation. There...Study protocolSat, 16 Mar 2024 00:00:00 GMThttps://trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-08013-zEmma Bamford, Hannah Berntsson, Suzanne Beale, Lauren Desoysa, Joseph Dias, Sienna Hamer-Kiwacz, Daniel Hind, Nick Johnson, Amanda Loban, Kaye Molloy, Emma Morvan, Ines Rombach, Anna Selby, Praveen Thokala, Chris Turtle, Stephen Walters…2024-03-16T00:00:00ZCorrection: Detailed statistical analysis plan for ALBINO: effect of Allopurinol in addition to hypothermia for hypoxic-ischemic Brain Injury on Neurocognitive Outcome — a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-08031-xCorrectionFri, 15 Mar 2024 00:00:00 GMThttps://trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-08031-xCorinna Engel, Mario Rüdiger, Manon J. N. L. Benders, Frank van Bel, Karel Allegaert, Gunnar Naulaers, Dirk Bassler, Katrin Klebermaß-Schrehof, Maximo Vento, Ana Vilan, Mari Falck, Isabella Mauro, Marjo Metsäranta, Sampsa Vanhatalo, Jan Mazela, Tuuli Metsvaht…2024-03-15T00:00:00ZMean Arterial Pressure (MAP) Trial: study protocol for a multicentre, randomized, controlled trial to compare three different strategies of mean arterial pressure management during cardiopulmonary bypasshttps://trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-07992-3One of the main goals of cardiopulmonary bypass (CPB) is targeting an adequate mean arterial pressure (MAP) during heart surgery, in order to maintain appropriate perfusion pressures in all end-organs. As inhe...Study protocolFri, 15 Mar 2024 00:00:00 GMThttps://trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-07992-3Alessandra Francica, Gina Mazzeo, Antonella Galeone, Daniele Linardi, Livio San Biagio, Giovanni Battista Luciani and Francesco Onorati2024-03-15T00:00:00ZHeart rate and breathing effects on attention and memory (HeartBEAM): study protocol for a randomized controlled trial in older adultshttps://trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-07943-yIn healthy people, the “fight-or-flight” sympathetic system is counterbalanced by the “rest-and-digest” parasympathetic system. As we grow older, the parasympathetic system declines as the sympathetic system b...Study protocolFri, 15 Mar 2024 00:00:00 GMThttps://trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-07943-yKaoru Nashiro, Hyun Joo Yoo, Christine Cho, Andy Jeesu Kim, Padideh Nasseri, Jungwon Min, Martin J. Dahl, Noah Mercer, Jeiran Choupan, Paul Choi, Hye Rynn J. Lee, David Choi, Kalekirstos Alemu, Alexandra Ycaza Herrera, Nicole F. Ng, Julian F. Thayer…2024-03-15T00:00:00ZTrials that turn from retrospectively registered to prospectively registered: a cohort study of “retroactively prospective” clinical trial registration using history datahttps://trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-08029-5Prospective registration of clinical trials is mandated by various regulations. However, clinical trial registries like ClinicalTrials.gov allow registry entries to be updated at any time, and key study elemen...ResearchThu, 14 Mar 2024 00:00:00 GMThttps://trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-08029-5Martin Holst and Benjamin Gregory Carlisle2024-03-14T00:00:00Z