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1.

1500
Accesses

Research   Open Access Highly Accessed

Data sharing among data monitoring committees and responsibilities to patients and science

Iain Chalmers, Douglas G Altman, Hazel McHaffie, Nancy Owens, Richard WI Cooke Trials 2013, 14:102 (19 April 2013)

Abstract | Full text | PDF

2.

905
Accesses

Research   Open Access

Systematic adjudication of myocardial infarction end-points in an international clinical trial

Kenneth W Mahaffey, Robert A Harrington, Martijn Akkerhuis, Neal S Kleiman, Lisa G Berdan, Brian S Crenshaw, Barbara E Tardiff, Christopher B Granger, Ingrid DeJong, Manju Bhapkar, Petr Widimsky, Ramón Corbalon, Kerry L Lee, Jaap W Deckers, Maarten L Simoons, Eric J Topol, Robert M Califf, for the PURSUIT Investigators Current Controlled Trials in Cardiovascular Medicine 2001, 2:180-186 (17 July 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

3.

609
Accesses

Study protocol   Open Access

Feasibility of omega-3 fatty acid supplementation as an adjunct therapy for people with chronic obstructive pulmonary disease: study protocol for a randomized controlled trial

Ashley S Fulton, Alison M Hill, Marie T Williams, Peter RC Howe, Peter A Frith, Lisa G Wood, Manohar L Garg, Alison M Coates Trials 2013, 14:107 (24 April 2013)

Abstract | Full text | PDF

4.

570
Accesses

Study protocol   Open Access

Ondansetron and simvastatin added to treatment as usual in patients with schizophrenia: study protocol for a randomized controlled trial

Imran B Chaudhry, Nusrat Husain, Mohammad O Husain, Jamie Hallak, Richard Drake, Ajmal Kazmi, Raza ur Rahman, Mohammad M Hamirani, Tayyaba Kiran, Nasir Mehmood, John Stirling, Graham Dunn, Bill Deakin Trials 2013, 14:101 (17 April 2013)

Abstract | Full text | PDF

5.

560
Accesses

Study protocol   Open Access Highly Accessed

The Healthy Lifestyles Programme (HeLP), a novel school-based intervention to prevent obesity in school children: study protocol for a randomised controlled trial

Katrina M Wyatt, Jennifer J Lloyd, Charles Abraham, Siobhan Creanor, Sarah Dean, Emma Densham, Wendy Daurge, Colin Green, Melvyn Hillsdon, Virginia Pearson, Rod S Taylor, Richard Tomlinson, Stuart Logan Trials 2013, 14:95 (4 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

6.

546
Accesses

Update   Open Access

Revising the ECRIN standard requirements for information technology and data management in clinical trials

Christian Ohmann, Steve Canham, Catherine Cornu, Jochen Dreß, François Gueyffier, Wolfgang Kuchinke, Enrico B Nicolis, Michael Wittenberg Trials 2013, 14:97 (5 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

7.

519
Accesses

Study protocol   Open Access

Efficacy of individualized homeopathic treatment and fluoxetine for moderate to severe depression in peri- and postmenopausal women (HOMDEP-MENOP): study protocol for a randomized, double-dummy, double-blind, placebo-controlled trial

Emma del Carmen Macías-Cortés, Leopoldo Aguilar-Faisal, Juan Asbun-Bojalil Trials 2013, 14:105 (23 April 2013)

Abstract | Full text | PDF

8.

511
Accesses

Review   Open Access Highly Accessed

Reporting bias in medical research - a narrative review

Natalie McGauran, Beate Wieseler, Julia Kreis, Yvonne-Beatrice Schüler, Heike Kölsch, Thomas Kaiser Trials 2010, 11:37 (13 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

9.

483
Accesses

Study protocol   Open Access Highly Accessed

Mobile phone text message intervention to reduce binge drinking among young adults: study protocol for a randomized controlled trial

Brian Suffoletto, Clifton W Callaway, Jeffrey Kristan, Peter Monti, Duncan B Clark Trials 2013, 14:93 (3 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

10.

482
Accesses

Study protocol   Open Access

Empiric versus imaging guided left ventricular lead placement in cardiac resynchronization therapy (ImagingCRT): study protocol for a randomized controlled trial

Anders Sommer, Mads Brix Kronborg, Steen Hvitfeldt Poulsen, Morten Böttcher, Bjarne Linde Nørgaard, Kirsten Bouchelouche, Peter Thomas Mortensen, Christian Gerdes, Jens Cosedis Nielsen Trials 2013, 14:113 (26 April 2013)

Abstract | Full text | PDF

11.

481
Accesses

Study protocol   Open Access

Mindfulness-based intervention for teenagers with cancer: study protocol for a randomized controlled trial

Catherine Malboeuf-Hurtubise, Marie Achille, Serge Sultan, Majorie Vadnais Trials 2013, 14:135 (10 May 2013)

Abstract | Full text | PDF | PubMed

12.

456
Accesses

Study protocol   Open Access

Making clinical trials more relevant: improving and validating the PRECIS tool for matching trial design decisions to trial purpose

Kirsty Loudon, Merrick Zwarenstein, Frank Sullivan, Peter Donnan, Shaun Treweek Trials 2013, 14:115 (27 April 2013)

Abstract | Full text | PDF

13.

441
Accesses

Study protocol   Open Access

Overshadowing as prevention of anticipatory nausea and vomiting in pediatric cancer patients: study protocol for a randomized controlled trial

Friedemann Geiger, Levke Wolfgram Trials 2013, 14:103 (20 April 2013)

Abstract | Full text | PDF

14.

440
Accesses

Review   Open Access Highly Accessed

The Blood Pressure "Uncertainty Range" – a pragmatic approach to overcome current diagnostic uncertainties (II)

Cornel Pater Current Controlled Trials in Cardiovascular Medicine 2005, 6:5 (6 April 2005)

Abstract | Full text | PDF | PubMed

15.

438
Accesses

Study protocol   Open Access

Effect of comprehensive cardiac rehabilitation after heart valve surgery (CopenHeartVR): study protocol for a randomised clinical trial

Kirstine Laerum Sibilitz, Selina Kikkenborg Berg, Tina Birgitte Hansen, Signe Stelling Risom, Trine Bernholdt Rasmussen, Christian Hassager, Lars Køber, Daniel Steinbrüchel, Christian Gluud, Per Winkel, Lau Caspar Thygesen, Jane Lindschou Hansen, Jean Paul Schmid, Viviane Conraads, Barbara Christina Brocki, Ann-Dorthe Zwisler Trials 2013, 14:104 (22 April 2013)

Abstract | Full text | PDF

16.

433
Accesses

Study protocol   Open Access

Enteral vs. intravenous ICU sedation management: study protocol for a randomized controlled trial

Giovanni Mistraletti, Elena S Mantovani, Paolo Cadringher, Barbara Cerri, Davide Corbella, Michele Umbrello, Stefania Anania, Elisa Andrighi, Serena Barello, Alessandra Carlo, Federica Martinetti, Paolo Formenti, Paolo Spanu, Gaetano Iapichino, for the SedaEN investigators Trials 2013, 14:92 (3 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

17.

431
Accesses

Research   Open Access

Intracluster correlation coefficients and coefficients of variation for perinatal outcomes from five cluster-randomised controlled trials in low and middle-income countries: results and methodological implications

Christina Pagel, Audrey Prost, Sonia Lewycka, Sushmita Das, Tim Colbourn, Rajendra Mahapatra, Kishwar Azad, Anthony Costello, David Osrin Trials 2011, 12:151 (14 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

18.

416
Accesses

Study protocol   Open Access Highly Accessed

Improving delirium care in the intensive care unit: The design of a pragmatic study

Noll L Campbell, Babar A Khan, Mark Farber, Tiffany Campbell, Anthony J Perkins, Siu L Hui, Greg Abernathy, John Buckley, Regg Sing, Jason Tricker, Mohammad Zawahiri, Malaz A Boustani Trials 2011, 12:139 (6 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

19.

413
Accesses

Study protocol   Open Access

INVESTIGATE-I (INVasive Evaluation before Surgical Treatment of Incontinence Gives Added Therapeutic Effect?): study protocol for a mixed methods study to assess the feasibility of a future randomised controlled trial of the clinical utility of invasive urodynamic testing

Megan Murdoch, Elaine McColl, Denise Howel, Mark Deverill, Brian S Buckley, Malcolm Lucas, Christopher R Chapple, Douglas G Tincello, Natalie Armstrong, Cath Brennand, Jing Shen, Luke Vale, Paul Hilton Trials 2011, 12:169 (6 July 2011)

Abstract | Full text | PDF | PubMed

20.

411
Accesses

Review   Open Access Highly Accessed

Managing clinical trials

Barbara Farrell, Sara Kenyon, Haleema Shakur Trials 2010, 11:78 (13 July 2010)

Abstract | Full text | PDF | PubMed | 1 comment

21.

412
Accesses

Study protocol   Open Access Highly Accessed

Bath Breakfast Project (BBP) - Examining the role of extended daily fasting in human energy balance and associated health outcomes: Study protocol for a randomised controlled trial [ISRCTN31521726]

James A Betts, Dylan Thompson, Judith D Richardson, Enhad A Chowdhury, Matthew Jeans, Geoffrey D Holman, Kostas Tsintzas Trials 2011, 12:172 (8 July 2011)

Abstract | Full text | PDF | PubMed

22.

412
Accesses

Study protocol   Open Access

Home-based reach-to-grasp training for people after stroke: study protocol for a feasibility randomized controlled trial

Ailie J Turton, Paul Cunningham, Emma Heron, Frederike van Wijck, Cath Sackley, Chris Rogers, Keith Wheatley, Sue Jowett, Steven L Wolf, Paulette van Vliet Trials 2013, 14:109 (25 April 2013)

Abstract | Full text | PDF

23.

411
Accesses

Study protocol   Open Access

Comparison of four skin preparation strategies to prevent catheter-related infection in intensive care unit (CLEAN trial): a study protocol for a randomized controlled trial

Véronique Goudet, Jean-François Timsit, Jean-Christophe Lucet, Alain Lepape, Dorothée Balayn, Sabrina Seguin, Olivier Mimoz Trials 2013, 14:114 (27 April 2013)

Abstract | Full text | PDF

24.

411
Accesses

Study protocol   Open Access Highly Accessed

The effects on depression of Internet-administered behavioural activation and physical exercise with treatment rationale and relapse prevention: study protocol for a randomised controlled trial

Per Carlbring, Philip Lindner, Christopher Martell, Peter Hassmén, Lars Forsberg, Lars Ström, Gerhard Andersson Trials 2013, 14:35 (2 February 2013)

Abstract | Full text | PDF | PubMed

25.

413
Accesses

Methodology   Open Access Highly Accessed

A cluster-randomized, placebo-controlled, maternal vitamin a or beta-carotene supplementation trial in bangladesh: design and methods

Alain B Labrique, Parul Christian, Rolf DW Klemm, Mahbubur Rashid, Abu Shamim, Allan Massie, Kerry Schulze, Andre Hackman, Keith P West Trials 2011, 12:102 (21 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

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