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1.

1463
Accesses

Commentary   Open Access

Six pairs of things to celebrate on International Clinical Trials Day

David L Sackett Trials 2013, 14:128 (20 May 2013)

Abstract | Provisional PDF | PubMed

2.

1049
Accesses

Research   Open Access Highly Accessed

Data sharing among data monitoring committees and responsibilities to patients and science

Iain Chalmers, Douglas G Altman, Hazel McHaffie, Nancy Owens, Richard WI Cooke Trials 2013, 14:102 (19 April 2013)

Abstract | Full text | PDF

3.

863
Accesses

Research   Open Access

Systematic adjudication of myocardial infarction end-points in an international clinical trial

Kenneth W Mahaffey, Robert A Harrington, Martijn Akkerhuis, Neal S Kleiman, Lisa G Berdan, Brian S Crenshaw, Barbara E Tardiff, Christopher B Granger, Ingrid DeJong, Manju Bhapkar, Petr Widimsky, Ramón Corbalon, Kerry L Lee, Jaap W Deckers, Maarten L Simoons, Eric J Topol, Robert M Califf, for the PURSUIT Investigators Current Controlled Trials in Cardiovascular Medicine 2001, 2:180-186 (17 July 2001)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

4.

610
Accesses

Review   Open Access Highly Accessed

Managing clinical trials

Barbara Farrell, Sara Kenyon, Haleema Shakur Trials 2010, 11:78 (13 July 2010)

Abstract | Full text | PDF | PubMed | 1 comment

5.

590
Accesses

Study protocol   Open Access

An open-label study of effects of acupuncture on chronic fatigue syndrome and idiopathic chronic fatigue: study protocol for a randomized controlled trial

Jung-Eun Kim, Kwon-Eui Hong, Hyeong-Jun Kim, Jin-Bong Choi, Yong-Hyeon Baek, Byung-Kwan Seo, Sanghun Lee, Kyung-Won Kang, Min-Hee Lee, Joo-Hee Kim, Seunghoon Lee, So-Young Jung, Hee-Jung Jung, Mi-Suk Shin, Sun-Mi Choi Trials 2013, 14:147 (21 May 2013)

Abstract | Provisional PDF | PubMed

6.

571
Accesses

Study protocol   Open Access

Feasibility of omega-3 fatty acid supplementation as an adjunct therapy for people with chronic obstructive pulmonary disease: study protocol for a randomized controlled trial

Ashley S Fulton, Alison M Hill, Marie T Williams, Peter RC Howe, Peter A Frith, Lisa G Wood, Manohar L Garg, Alison M Coates Trials 2013, 14:107 (24 April 2013)

Abstract | Full text | PDF

7.

570
Accesses

Study protocol   Open Access

Mindfulness-based intervention for teenagers with cancer: study protocol for a randomized controlled trial

Catherine Malboeuf-Hurtubise, Marie Achille, Serge Sultan, Majorie Vadnais Trials 2013, 14:135 (10 May 2013)

Abstract | Full text | PDF | ePUB | PubMed

8.

568
Accesses

Review   Open Access Highly Accessed

Reporting bias in medical research - a narrative review

Natalie McGauran, Beate Wieseler, Julia Kreis, Yvonne-Beatrice Schüler, Heike Kölsch, Thomas Kaiser Trials 2010, 11:37 (13 April 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

9.

520
Accesses

Research   Open Access Highly Accessed

Intracluster correlation coefficients and coefficients of variation for perinatal outcomes from five cluster-randomised controlled trials in low and middle-income countries: results and methodological implications

Christina Pagel, Audrey Prost, Sonia Lewycka, Sushmita Das, Tim Colbourn, Rajendra Mahapatra, Kishwar Azad, Anthony Costello, David Osrin Trials 2011, 12:151 (14 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

10.

522
Accesses

Study protocol   Open Access

INVESTIGATE-I (INVasive Evaluation before Surgical Treatment of Incontinence Gives Added Therapeutic Effect?): study protocol for a mixed methods study to assess the feasibility of a future randomised controlled trial of the clinical utility of invasive urodynamic testing

Megan Murdoch, Elaine McColl, Denise Howel, Mark Deverill, Brian S Buckley, Malcolm Lucas, Christopher R Chapple, Douglas G Tincello, Natalie Armstrong, Cath Brennand, Jing Shen, Luke Vale, Paul Hilton Trials 2011, 12:169 (6 July 2011)

Abstract | Full text | PDF | PubMed

11.

519
Accesses

Study protocol   Open Access

Empiric versus imaging guided left ventricular lead placement in cardiac resynchronization therapy (ImagingCRT): study protocol for a randomized controlled trial

Anders Sommer, Mads Brix Kronborg, Steen Hvitfeldt Poulsen, Morten Böttcher, Bjarne Linde Nørgaard, Kirsten Bouchelouche, Peter Thomas Mortensen, Christian Gerdes, Jens Cosedis Nielsen Trials 2013, 14:113 (26 April 2013)

Abstract | Full text | PDF

12.

517
Accesses

Study protocol   Open Access Highly Accessed

Bath Breakfast Project (BBP) - Examining the role of extended daily fasting in human energy balance and associated health outcomes: Study protocol for a randomised controlled trial [ISRCTN31521726]

James A Betts, Dylan Thompson, Judith D Richardson, Enhad A Chowdhury, Matthew Jeans, Geoffrey D Holman, Kostas Tsintzas Trials 2011, 12:172 (8 July 2011)

Abstract | Full text | PDF | PubMed

13.

504
Accesses

Study protocol   Open Access

Making clinical trials more relevant: improving and validating the PRECIS tool for matching trial design decisions to trial purpose

Kirsty Loudon, Merrick Zwarenstein, Frank Sullivan, Peter Donnan, Shaun Treweek Trials 2013, 14:115 (27 April 2013)

Abstract | Full text | PDF

14.

483
Accesses

Methodology   Open Access Highly Accessed

A cluster-randomized, placebo-controlled, maternal vitamin a or beta-carotene supplementation trial in bangladesh: design and methods

Alain B Labrique, Parul Christian, Rolf DW Klemm, Mahbubur Rashid, Abu Shamim, Allan Massie, Kerry Schulze, Andre Hackman, Keith P West Trials 2011, 12:102 (21 April 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

15.

480
Accesses

Research   Open Access

Pilot randomized trial of therapeutic hypothermia with serial cranial ultrasound and 18-22 month follow-up for neonatal encephalopathy in a low resource hospital setting in uganda: study protocol

Nicola J Robertson, Cornelia F Hagmann, Dominique Acolet, Elizabeth Allen, Natasha Nyombi, Diana Elbourne, Anthony Costello, Ian Jacobs, Margaret Nakakeeto, Frances Cowan Trials 2011, 12:138 (4 June 2011)

Abstract | Full text | PDF | PubMed

16.

477
Accesses

Study protocol   Open Access

Immediate vs. delayed insertion of intrauterine contraception after second trimester abortion: study protocol for a randomized controlled trial

Wendy V Norman, Janusz Kaczorowski, Judith A Soon, Rollin Brant, Stirling Bryan, Konia J Trouton, Lyda Dicus Trials 2011, 12:149 (14 June 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

17.

464
Accesses

Study protocol   Open Access

The Chest Pain Choice trial: a pilot randomized trial of a decision aid for patients with chest pain in the emergency department

Meghan A Pierce, Erik P Hess, Jeffrey A Kline, Nilay D Shah, Maggie Breslin, Megan E Branda, Laurie J Pencille, Brent R Asplin, David M Nestler, Annie T Sadosty, Ian G Stiell, Henry H Ting, Victor M Montori Trials 2010, 11:57 (17 May 2010)

Abstract | Full text | PDF | PubMed

18.

461
Accesses

Study protocol   Open Access

Home-based reach-to-grasp training for people after stroke: study protocol for a feasibility randomized controlled trial

Ailie J Turton, Paul Cunningham, Emma Heron, Frederike van Wijck, Cath Sackley, Chris Rogers, Keith Wheatley, Sue Jowett, Steven L Wolf, Paulette van Vliet Trials 2013, 14:109 (25 April 2013)

Abstract | Full text | PDF

19.

460
Accesses

Study protocol   Open Access

LigaSure Impact™ versus conventional dissection technique in pylorus-preserving pancreatoduodenectomy in clinical suspicion of cancerous tumours on the head of the pancreas: study protocol for a randomised controlled trial

Tobias Gehrig, Phillip Knebel, Verena Scheel, Ulf Hinz, Christoph M Seiler, Beat P Müller-Stich, Markus W Büchler, Carsten N Gutt Trials 2011, 12:162 (29 June 2011)

Abstract | Full text | PDF | PubMed

20.

459
Accesses

Study protocol   Open Access

Efficacy of a dilemma-focused intervention for unipolar depression: study protocol for a multicenter randomized controlled trial

Guillem Feixas, Arturo Bados, Eugeni García-Grau, Adrián Montesano, Gloria Dada, Victoria Compañ, Mari Aguilera, Marta Salla, Joan Soldevilla, Adriana Trujillo, Clara Paz, Lluís Botella, Sergi Corbella, Luis Saúl-Gutiérrez, José Cañete, Miquel Gasol, Montserrat Ibarra, Leticia Medeiros-Ferreira, José Soriano, Eugénia Ribeiro, Franz Caspar, David Winter Trials 2013, 14:144 (17 May 2013)

Abstract | Full text | PDF | PubMed

21.

457
Accesses

Study protocol   Open Access

Comparison of four skin preparation strategies to prevent catheter-related infection in intensive care unit (CLEAN trial): a study protocol for a randomized controlled trial

Véronique Goudet, Jean-François Timsit, Jean-Christophe Lucet, Alain Lepape, Dorothée Balayn, Sabrina Seguin, Olivier Mimoz Trials 2013, 14:114 (27 April 2013)

Abstract | Full text | PDF

22.

456
Accesses

Review   Open Access Highly Accessed

The Blood Pressure "Uncertainty Range" – a pragmatic approach to overcome current diagnostic uncertainties (II)

Cornel Pater Current Controlled Trials in Cardiovascular Medicine 2005, 6:5 (6 April 2005)

Abstract | Full text | PDF | PubMed

23.

454
Accesses

Study protocol   Open Access

Can a management pathway for chronic cough in children improve clinical outcomes: protocol for a multicentre evaluation

AB Chang, CF Robertson, PP van Asperen, NJ Glasgow, IB Masters, CM Mellis, LI Landau, L Teoh, PS Morris Trials 2010, 11:103 (6 November 2010)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

24.

451
Accesses

Study protocol   Open Access

Strategic use of new generation antidepressants for depression: SUN(^_^)D study protocol

Toshi A Furukawa, Tatsuo Akechi, Shinji Shimodera, Mitsuhiko Yamada, Kazuhira Miki, Norio Watanabe, Masatoshi Inagaki, Naohiro Yonemoto Trials 2011, 12:116 (11 May 2011)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central

25.

450
Accesses

Study protocol   Open Access Highly Accessed

The Healthy Lifestyles Programme (HeLP), a novel school-based intervention to prevent obesity in school children: study protocol for a randomised controlled trial

Katrina M Wyatt, Jennifer J Lloyd, Charles Abraham, Siobhan Creanor, Sarah Dean, Emma Densham, Wendy Daurge, Colin Green, Melvyn Hillsdon, Virginia Pearson, Rod S Taylor, Richard Tomlinson, Stuart Logan Trials 2013, 14:95 (4 April 2013)

Abstract | Full text | PDF | ePUB | PubMed

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