Most Accessed Articles: Trialshttps://trialsjournal.biomedcentral.comMost Accessed Articles: TrialsPalliative long-term abdominal drains versus repeated drainage in individuals with untreatable ascites due to advanced cirrhosis: study protocol for a feasibility randomised controlled trialhttps://trialsjournal.biomedcentral.com/articles/10.1186/s13063-018-2779-0UK deaths due to chronic liver diseases such as cirrhosis have quadrupled over the last 40 years, making this condition now the third most common cause of premature death. Most patients with advanced cirrhosis...Study protocolFri, 27 Jul 2018 00:00:00 GMThttps://trialsjournal.biomedcentral.com/articles/10.1186/s13063-018-2779-0Lucia Macken, Louise Mason, Catherine Evans, Heather Gage, Jake Jordan, Mark Austin, Nick Parnell, Max Cooper, Shani Steer, Justine Boles, Stephen Bremner, Debbie Lambert, David Crook, Gemma Earl, Jean Timeyin and Sumita Verma2018-07-27T00:00:00ZThrough the looking glass: understanding non-inferiorityhttps://trialsjournal.biomedcentral.com/articles/10.1186/1745-6215-12-106Non-inferiority trials test whether a new product is not unacceptably worse than a product already in use. This paper introduces concepts related to non-inferiority, and discusses the regulatory views of both ...ReviewTue, 03 May 2011 00:00:00 GMThttps://trialsjournal.biomedcentral.com/articles/10.1186/1745-6215-12-106Jennifer Schumi and Janet T Wittes2011-05-03T00:00:00ZOral corticosteroids for post-infectious cough in adults: study protocol for a double-blind randomized placebo-controlled trial in Swiss family practices (OSPIC trial)https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04848-4Cough is a common reason for patients to visit general practices. So-called post-infectious cough is defined as lasting 3 to 8 weeks after an upper respiratory tract infection. It can be disabling in daily act...Study protocolMon, 23 Nov 2020 00:00:00 GMThttps://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04848-4Christoph Merlo, Stefan Essig, D. Oana Brancati-Badarau, Jörg Daniel Leuppi, Benjamin Speich, Tobias E. Erlanger, Lars G. Hemkens and Andreas Zeller2020-11-23T00:00:00ZSample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation studyhttps://trialsjournal.biomedcentral.com/articles/10.1186/1745-6215-15-264External pilot or feasibility studies can be used to estimate key unknown parameters to inform the design of the definitive randomised controlled trial (RCT). However, there is little consensus on how large pi...ResearchThu, 03 Jul 2014 00:00:00 GMThttps://trialsjournal.biomedcentral.com/articles/10.1186/1745-6215-15-264M Dawn Teare, Munyaradzi Dimairo, Neil Shephard, Alex Hayman, Amy Whitehead and Stephen J Walters2014-07-03T00:00:00ZManaging clinical trialshttps://trialsjournal.biomedcentral.com/articles/10.1186/1745-6215-11-78Managing clinical trials, of whatever size and complexity, requires efficient trial management. Trials fail because tried and tested systems handed down through apprenticeships have not been documented, evalua...ReviewTue, 13 Jul 2010 00:00:00 GMThttps://trialsjournal.biomedcentral.com/articles/10.1186/1745-6215-11-78Barbara Farrell, Sara Kenyon and Haleema Shakur2010-07-13T00:00:00Z