Trials is an open access, peer-reviewed, online journal that encompasses all aspects of the performance and findings of randomized controlled trials in health. We publish articles on general trial methodology as well as protocols, commentaries and traditional results papers - regardless of outcome or significance of findings.

Editors-in-Chief

  • Doug Altman, University of Oxford
  • Curt Furberg, Wake Forest University of Medicine
  • Jeremy Grimshaw, Ottawa Health Research Institute

Articles

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  • Effects of motivational interviewing-based adherence therapy for schizophrenia spectrum disorders

    Long-term treatment in schizophrenia and other psychotic disorders can be difficult due to non-adherence to antipsychotic medication. Motivational interviewing-based adherence therapy for people with schizophrenia was seen to improve medication adherence, as well as reduce symptom severity and re-hospitalizations.

    Trials 2015, 16:270
  • Making randomized trials more efficient

    RCTs are gold standard for investigating cause-and-effect in healthcare. However, the evidence base for conducting RCTs is limited; the Trial Forge initiative aims to overcome this, and this article summarizes their first meeting.

    Trials 2015, 16:261
  • Image attributed to: Gudavalli et al. Trials 2015 16:259

    Development of an attention-touch control for manual cervical distraction

    Manual cervical distraction is a traction-based therapy used to alleviate neck pain. A mixed-methods, pilot RCT evaluated a traction-based, minimal intervention as an attention-touch control for future efficacy trials of manual cervical distraction.

    Trials 2015, 16:259
  • CONSORT in China

    The CONSORT Statement provides guidance for the complete and transparent reporting of RCTs; this study shows that RCT reports in Chinese journals needs improvement and those journals that have adopted the CONSORT Statement have a better quality of RCT reports within their journals.

    Trials 2015, 16:243
  • Photographic analysis of wound epithelialization

    The primary endpoint for clinical trials of cutaneous healing is wound closure. Remote photographic analysis of cutaneous wounds to evaluate wound closure in human skin graft donor sites and epidermolysis bullosa wounds was not only feasible but also reliable.

    Trials 2015, 16:235

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Trials reporting

Trials advocates the complete and transparent reporting of research. Authors are required to adhere to the CONSORT Statement for any submitted clinical trials, and encouraged to follow the SPIRIT Statement for study protocols. The Editors also encourage authors to follow any relevant extensions to the CONSORT Statement, available from the EQUATOR Network.

Editor's profile

Doug Altman

Altman Doug
Professor Doug Altman graduated in statistics from the University of Bath and has worked for the Medical Research Council as a statistical consultant in a wide variety of medical areas. In 1988 he became head of the newly formed Medical Statistics Laboratory (now Medical Statistics Group) at ICRF (now Cancer Research UK), and in 1995 also became founding director of the Centre for Statistics in Medicine (CSM) in Oxford. In 1997, Professor Altman received the Bradford Hill Medal for his contributions to medical statistics and a DSc from the University of London and, in 1998 was made Professor of Statistics in Medicine by the University of Oxford. His varied research interests include the use and abuse of statistics in medical research, studies of prognosis, regression modelling, systematic reviews and meta-analysis, randomised trials, and studies of medical measurement.

Curt D. Furberg

Curt D. Furberg
Professor Curt D. Furberg is a co-Editor-in-Chief of Trials. He is a Professor of Public Health at Wake Forest University Health Sciences, where he has been since 1986. Professor Furberg earned his MD in Sweden in 1963 and has worked at the Minneapolis LRC Clinic as the Chief of the Clinical Trials Branch and the Clinical Trials Research Branch of the National Heart, Lung, and Blood Institute - where he was the Associate Director for the Clinical Applications and Prevention Program. In addition, Professor Furberg is a nationally and internationally recognized expert on the design, conduct, analysis and monitoring of clinical trials. He has worked closely with investigators at the NIH and several pharmaceutical companies and is also a world-renowned cardiovascular epidemiologist with special expertise in lipid-lowering and blood pressure-lowering therapies. He is a strong proponent for evidence-based medicine, and his public health background provides a strong foundation for his views on drug evaluation and patient safety.

Jeremy Grimshaw

Jeremy Grimshaw
Professor Jeremy Grimshaw is the Director of the Clinical Epidemiology Program at the Ottawa Health Research Institute and the Director of the Center for Best Practice at the University of Ottawa. He holds a Tier 1 Canadian Research Chair in health knowledge transfer and uptake and was made a Professor of Medicine by the University of Ottawa. Prior to this, he held a Personal Chair in health services research at the University of Aberdeen and was the Program Director of the Effective Professional Program within health services research, one of the largest implementation research programs within the UK. Professor Grimshaw’s research interests are in knowledge translation,quality improvement,complex interventions. systematic reviews, cluster randomized trials, quasi experimental studies and behavioural theories (and their application to professional behaviour).

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Latest supplements

Volume 16 Suppl 1 (29 May 2015)

Abstracts of the 4th Meeting of the Core Outcome Measures in Effectiveness Trials (COMET) Initiative

Meeting abstracts
Rome, Italy. 19-20 November 2014

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ISSN: 1745-6215