|Description of interventions in phase 2|
|Abbreviated name for trial||Aim of trial||Setting and wider context||Nature of intervention||Nature of control intervention(s)|
|Phase 2: Multiple explanatory case study|
|Aim: To seek empirical support for the theoretical propositions and assess likely validity across multiple trial types and contexts|
|Trial 1: Waiting list||To determine whether patients and their partners who receive an extended home-based programme of pre-cardiac surgery education and support demonstrate equal or greater benefit compared with those who receive a short hospital- based programme||NHS Health Board covering a large geographical area with no cardiac surgery. Contract with a neighbouring Health Board for cardiac surgery. Mixed urban/rural, affluent/ deprived population, with a range of GP practices (single-handed to group practices)||Education and support intervention for patients on waiting list for coronary artery bypass surgery, delivered over six months with alternate monthly home and practice nurse visits||One-off three-hour education and support class delivered in hospital setting for patients in the same target group, soon after joining the waiting list|
|Trial 2: Information||To evaluate the benefits of a new information leaflet given to parents/guardians when their child is discharged from hospital following a benign febrile convulsion||Paediatric unit in large teaching hospital in Scotland||An information leaflet for parents of children with benign febrile convulsions, designed to meet current standards of written information||An information leaflet for the same target group, not designed to meet current standards of written information|
|Trial 3: Exercise||To determine the acceptability and effects of an aerobic exercise intervention during radiotherapy for localised prostate cancer on fatigue||Cancer centre in Scotland||Exercise intervention to reduce fatigue in patients undergoing four weeks of radiotherapy for prostate cancer. One to one session with physiotherapist for tailored exercise instruction||A weekly phone call with a clinical nurse specialist. No specific exercise guidance|
|Trial 4: CBT||To assess the relative efficacy in routine practiceof clinical nurse specialists providing cognitive-behaviour therapy for psychotic patients suffering from chronic, distressing symptoms only partially relieved by medication||Hospital and community psychiatric services in a large Health Board in Scotland||Twenty sessions of cognitive behavioural therapy, delivered over nine months, for patients with medication-resistant psychotic symptoms||Two controls: 1) usual psychiatric care 2) twenty supportive psychotherapy sessions|
|Trial 5: Guidelines||To determine the effectiveness of a national guideline in improving quality of life in epilepsy sufferers. To evaluate the effectiveness of two different implementation strategies for this guideline||General practices in a large Health Board area in Scotland||Interactive workshops, structured record sheets and specialist nurse facilitation to improve the management of epilepsy through clinical guidelines||Two controls: 1) guideline only sent to GP practices 2) interactive workshops and structured record sheets but no specialist nurse input|
|Trial 6: Sleep||To examine the impact of disorders of initiating and maintaining sleep on mothers’ mental health. To evaluate the cost effectiveness of a tailored sleep programme, provided by health visitors, in improving the mother’s mental health and the child’s sleep disorder||Fifteen GP practices within a large Health Board area in Scotland parents for children’s sleep||Tailored behavioural intervention programme delivered to disorders by a health visitor over six weekly sessions||Two controls: 1) information booklet only 2) waiting list for programme|
|Carers||To evaluate the effectiveness of a community mental health nurse (CMHN)-led intervention in supporting carers who look after a person who is diagnosed with schizophrenia. The intervention was compared with support that is normally offered to carers by CMHNs||Two Health Board areas in Scotland. Recruitment also took place through local carer support groups||Supportive intervention to meet the needs of carers of people with schizophrenia, delivered at home over twelve weeks by nurses trained to provide a carer-focused intervention||Supportive intervention to same target group, delivered over twelve weeks by nurses not trained to provide a carer-focused intervention|
CMHN, community mental health nurse; GP, general practitioner; NHS, National Health Service.
Wells et al.
Wells et al. Trials 2012 13:95 doi:10.1186/1745-6215-13-95