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Trials publishes selected collections of research articles, conference proceedings, reviews and reports as supplements, which are free to access online. All articles published in supplements are subject to peer review; meeting abstracts undergo review and selection by the conference. Find out more about publishing a supplement with BioMed Central.

Volume 12 Supplement 1

Clinical Trials Methodology Conference 2011

Meeting abstracts

Clinical Trials Methodology Conference 2011

Bristol, UK

4-5 October 2011

Edited by Stephanie McAvoy and Emily Crowe

This conference was sponsored by the Network of Hubs for Trials Methodology Research

Additional Information | Conference website

Invited speaker presentation   Open Access

Adaptive designs: current status, future outlook

Andy Grieve Trials 2011, 12(Suppl 1):A1 (13 December 2011)

Full text | PDF | PubMed

Oral presentation   Open Access

An adaptive seamless phase II/III clinical trial design incorporating short-term endpoint information

Nigel Stallard Trials 2011, 12(Suppl 1):A2 (13 December 2011)

Full text | PDF

Oral presentation   Open Access

Flexible trial design in practice – dropping and adding arms in STAMPEDE: a multi-arm multi-stage randomised controlled trial

Matthew R Sydes, Nicholas D James, Malcolm D Mason, Noel W Clarke, Claire Amos, John Anderson, Johann de Bono, David P Dearnaley, John Dwyer, Gordana Jovic, Alastair Ritchie, Martin Russell, Karen Sanders, George Thalmann, Mahesh KB Parmar Trials 2011, 12(Suppl 1):A3 (13 December 2011)

Full text | PDF

Oral presentation   Open Access

Optimal design for multi-arm multi-stage clinical trials

James MS Wason, Thomas Jaki Trials 2011, 12(Suppl 1):A4 (13 December 2011)

Full text | PDF

Poster presentation   Open Access

Model selection and sample size adaptation: HYPAZ trial

Simon Bond, Adrian Mander, Duncan Jodrell, Joseph Cheryian Trials 2011, 12(Suppl 1):A5 (13 December 2011)

Full text | PDF

Poster presentation   Open Access

How Cancer Research UK is adapting to adaptive designs

Julie Hearn, Nicola Keat, Kate Law, Rowena Sharpe Trials 2011, 12(Suppl 1):A6 (13 December 2011)

Full text | PDF

Poster presentation   Open Access

The importance of planning for a seamless transition in an adaptive phase II randomised trial

Andrea Marshall, Janet A Dunn, Julie Fletcher, Helen B Higgins, Christopher J Poole Trials 2011, 12(Suppl 1):A7 (13 December 2011)

Full text | PDF

Poster presentation   Open Access

Software tools for implementing simulation studies in adaptive seamless designs: introducing R package ASD

Nick Parsons, Tim Friede, Susan Todd, Nigel Stallard Trials 2011, 12(Suppl 1):A8 (13 December 2011)

Full text | PDF

Invited speaker presentation   Open Access

Adverse effects

Stephen JW Evans Trials 2011, 12(Suppl 1):A9 (13 December 2011)

Full text | PDF

Oral presentation   Open Access

Eliciting harms data from trial participants: how perceptions of illness and treatment mediate recognition of relevant information to report

Elizabeth N Allen, Karen I Barnes, Adiel Mushi, Isolide Massawe, Sarah G Staedke, Ushma Mehta, Lasse S Vestergaard, Martha M Lemnge, Clare I Chandler Trials 2011, 12(Suppl 1):A10 (13 December 2011)

Full text | PDF

Oral presentation   Open Access

Anti-epileptic drug harms: issues for meta-analysis

Catrin Smith, Arif Shukralla, Sarah Donegan, Karla Hemming, Graham A Powell, Paula Williamson, Anthony Marson Trials 2011, 12(Suppl 1):A11 (13 December 2011)

Full text | PDF

Poster presentation   Open Access

Adverse event reporting in randomised trials of neuropathic pain: challenges for clinical usefulness of safety data

Victoria R Cornelius, Odile Sauzet, Salma Ayis, Joy Ross, Paul Farquhar-Smith, Ruth A Branford, John E Williams, Janet L Peacock Trials 2011, 12(Suppl 1):A12 (13 December 2011)

Full text | PDF

Poster presentation   Open Access

Documentation of adverse events in non-commercial trials of intravitreal injection of anti-VEGF drugs to treat wet age-related macular degeneration (AMD)

Barnaby C Reeves, Wendy Underwood, Heike Cappel-Porter, Sarah Baos, Chris A Rogers, Michael Arnott, Simon P Harding, Usha Chakravarthy, Alex E Foss Trials 2011, 12(Suppl 1):A13 (13 December 2011)

Full text | PDF

Invited speaker presentation   Open Access

Using biomarkers prospectively in adaptive clinical trials

Donald A Berry Trials 2011, 12(Suppl 1):A14 (13 December 2011)

Full text | PDF | PubMed

Oral presentation   Open Access

Data modeling methods in clinical trials: experiences from the clinical trial methods in neurodegenerative diseases project

Athanasios Anastasiou, Emmanuel Ifeachor, John Zajicek Trials 2011, 12(Suppl 1):A15 (13 December 2011)

Full text | PDF

Oral presentation   Open Access

Stratified medicine in practice: review of predictive biomarkers in European Medicines Agency (EMA) indications

Kinga Malottki, Mousumi Biswas, Jon Deeks, Richard Riley, Charles Craddock, Lucinda Billingham Trials 2011, 12(Suppl 1):A16 (13 December 2011)

Full text | PDF

Oral presentation   Open Access

Designing a preliminary adaptive study to inform a biomarker trial in Psoriasis

Andrew T Prevost, Jack Bowden Trials 2011, 12(Suppl 1):A17 (13 December 2011)

Full text | PDF

Poster presentation   Open Access

Selection of subjects for clinical trials in Alzheimer’s disease and mild cognitive impairment with machine learning analysis of MRI and CSF biomarkers

Javier Escudero, John P Zajicek, Emmanuel Ifeachor Trials 2011, 12(Suppl 1):A18 (13 December 2011)

Full text | PDF

Poster presentation   Open Access

Comparing diagnostic tests and biomarkers: trials in people with discordant test results

Richard Hooper, Karla Díaz-Ordaz, Andrea Takeda, Khalid Khan Trials 2011, 12(Suppl 1):A19 (13 December 2011)

Full text | PDF

Poster presentation   Open Access

Choice of transformation for modelling non-linear continuous biomarkers

Deborah D Stocken, Lucinda J Billingham, Philip J Johnson, Nick Freemantle Trials 2011, 12(Suppl 1):A20 (13 December 2011)

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